Cardiorespiratory interactions in neural circulatory control in humans

Abu S.M. Shamsuzzaman, Virend K. Somers

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The reflex mechanisms and interactions described in this overview provide some explanation for the range of neural circulatory responses evident during changes in breathing. The effects described represent the integrated responses to activation of several reflex mechanisms, including peripheral and central chemoreflexes, arterial baroreflexes, pulmonary stretch receptors, and ventricular mechanoreceptors. These interactions occur on a dynamic basis and the transfer characteristics of any single interaction are, in all likelihood, also highly dynamic. Nevertheless, it is only by attempting to understand individual reflexes and their modulating influences that a more thorough understanding of the responses to complex phenomena such as hyperventilation, apnea, and obstructive sleep apnea can be better understood.

Original languageEnglish (US)
Pages (from-to)488-499
Number of pages12
JournalAnnals of the New York Academy of Sciences
StatePublished - 2001


  • Baroreflexes
  • Chemoreflexes
  • Hyperventilation
  • Hypoxemia
  • Mueller maneuver
  • Pulmonary afferents
  • Sleep apnea

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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