Cardiopulmonary consequences of obstructive sleep apnea

Sean M. Caples, Tomas Kara, Virend K. Somers

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Ongoing research in obstructive sleep apnea (OSA) suggests strong associations with cardiopulmonary disorders. There is an abundance of studies describing physiological pathways in OSA that acutely impact the cardiovascular system. These mechanisms, if proven to carry over into the daytime hours, could form the basis for clinical disease. The challenge remains in disentangling these mechanistic processes from the many comorbid conditions often present in patients with OSA. Examples include male gender, obesity, and diabetes mellitus, all of which exert their own influence on the development of cardiopulmonary disease. This review discusses some of the physiological mechanisms associated with disordered breathing during sleep and explores putative cardiopulmonary disease associations.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalSeminars in Respiratory and Critical Care Medicine
Issue number1
StatePublished - Feb 2005


  • Cardiovascular disease
  • Hypoventilation
  • Obesity
  • Obstructive sleep apnea
  • Sleep-disordered breathing

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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