TY - JOUR
T1 - Cardiometabolic and endocrine comorbidities in women with bipolar disorder
T2 - A systematic review
AU - Pahwa, Mehak
AU - Kucuker, Mehmet U.
AU - Ho, Man Choi
AU - Puspitasari, Ajeng
AU - Moore, Katherine M.
AU - Betcher, Hannah K.
AU - Frye, Mark A.
AU - Singh, Balwinder
AU - Ozerdem, Aysegul
AU - Veldic, Marin
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/2/15
Y1 - 2023/2/15
N2 - Introduction: Bipolar Disorder (BD) is known to be equally distributed among males and females. The well-documented increased risk of medical comorbidities in patients with BD, in comparison to BD patients without medical comorbidities, shows a negative impact on the course of illness. There is some evidence suggesting that women with BD have higher psychiatric and medical comorbidities in comparison to men with BD, however there is no evidence in comparison to women without BD or other major psychiatric illness. These comorbidities, along with various psychosocial factors, are known to affect the course of BD. Methods: We aimed to systematically review the literature on cardiovascular, metabolic and endocrine comorbidities in women with BD in comparison to men with BD and control women. A comprehensive search of electronic databases including PubMed, PsycINFO, Embase, and SCOPUS was conducted, and a total of 61 identified studies were included in this review. Results: Women with BD had higher rates of cardiovascular risk factors/mortality, diabetes mellitus II and thyroid disorders compared to women in the general population. In comparison to men with BD, women with BD had comparable cardiovascular risk but higher prevalence of metabolic and thyroid disorders. Limitations: Gender specific data was limited in multiple studies. Conclusions: Results present a need for gender-specific screening and interventions for various medical comorbidities in patients with BD.
AB - Introduction: Bipolar Disorder (BD) is known to be equally distributed among males and females. The well-documented increased risk of medical comorbidities in patients with BD, in comparison to BD patients without medical comorbidities, shows a negative impact on the course of illness. There is some evidence suggesting that women with BD have higher psychiatric and medical comorbidities in comparison to men with BD, however there is no evidence in comparison to women without BD or other major psychiatric illness. These comorbidities, along with various psychosocial factors, are known to affect the course of BD. Methods: We aimed to systematically review the literature on cardiovascular, metabolic and endocrine comorbidities in women with BD in comparison to men with BD and control women. A comprehensive search of electronic databases including PubMed, PsycINFO, Embase, and SCOPUS was conducted, and a total of 61 identified studies were included in this review. Results: Women with BD had higher rates of cardiovascular risk factors/mortality, diabetes mellitus II and thyroid disorders compared to women in the general population. In comparison to men with BD, women with BD had comparable cardiovascular risk but higher prevalence of metabolic and thyroid disorders. Limitations: Gender specific data was limited in multiple studies. Conclusions: Results present a need for gender-specific screening and interventions for various medical comorbidities in patients with BD.
KW - Bipolar disorder
KW - Medical comorbidities
KW - Women
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U2 - 10.1016/j.jad.2022.12.023
DO - 10.1016/j.jad.2022.12.023
M3 - Review article
C2 - 36538952
AN - SCOPUS:85144750511
SN - 0165-0327
VL - 323
SP - 841
EP - 859
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -