Cardio Phenotypic Potential of Mesenchymal Stem Cells

Karen M. Peterson; Federico Franchi; M. Olthoff; Ramasamy Paulmurugan; Martin Rodriguez-Porcel

doi:10.1002/cpz1.62

Cardio Phenotypic Potential of Mesenchymal Stem Cells

Karen M. Peterson, Federico Franchi, M. Olthoff, Ramasamy Paulmurugan, Martin Rodriguez-Porcel

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Cell therapy is being investigated as a powerful intervention to ameliorate the consequences of coronary artery disease. Among the different stem cell options, mesenchymal stem cells (MSCs) are particularly attractive due to their high availability, as well as immune-privileged status. However, it is still unclear whether mesenchymal stem cells can acquire cardiomyogenic characteristics after they are transplanted to the myocardium. In this article, we outline protocols that illustrate the plasticity of MSCs and their ability to acquire cardiogenic characteristics when they are in an ischemic-like environment, as typically encountered after transplantation into the ischemic heart.

Original language	English (US)
Article number	e62
Journal	Current Protocols
Volume	1
Issue number	3
DOIs	https://doi.org/10.1002/cpz1.62
State	Published - Mar 2021

Keywords

cardiogenic
luciferase
mesenchymal stem cells
neonatal cardiomyocytes

ASJC Scopus subject areas

General Immunology and Microbiology
General Pharmacology, Toxicology and Pharmaceutics
Medical Laboratory Technology
General Biochemistry, Genetics and Molecular Biology
Health Informatics
General Neuroscience

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10.1002/cpz1.62

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abstract = "Cell therapy is being investigated as a powerful intervention to ameliorate the consequences of coronary artery disease. Among the different stem cell options, mesenchymal stem cells (MSCs) are particularly attractive due to their high availability, as well as immune-privileged status. However, it is still unclear whether mesenchymal stem cells can acquire cardiomyogenic characteristics after they are transplanted to the myocardium. In this article, we outline protocols that illustrate the plasticity of MSCs and their ability to acquire cardiogenic characteristics when they are in an ischemic-like environment, as typically encountered after transplantation into the ischemic heart.",

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AU - Rodriguez-Porcel, Martin

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AB - Cell therapy is being investigated as a powerful intervention to ameliorate the consequences of coronary artery disease. Among the different stem cell options, mesenchymal stem cells (MSCs) are particularly attractive due to their high availability, as well as immune-privileged status. However, it is still unclear whether mesenchymal stem cells can acquire cardiomyogenic characteristics after they are transplanted to the myocardium. In this article, we outline protocols that illustrate the plasticity of MSCs and their ability to acquire cardiogenic characteristics when they are in an ischemic-like environment, as typically encountered after transplantation into the ischemic heart.

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KW - neonatal cardiomyocytes

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Cardio Phenotypic Potential of Mesenchymal Stem Cells

Abstract

Keywords

ASJC Scopus subject areas

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