Cardio Phenotypic Potential of Mesenchymal Stem Cells

Karen M. Peterson, Federico Franchi, M. Olthoff, Ramasamy Paulmurugan, Martin Rodriguez-Porcel

Research output: Contribution to journalArticlepeer-review


Cell therapy is being investigated as a powerful intervention to ameliorate the consequences of coronary artery disease. Among the different stem cell options, mesenchymal stem cells (MSCs) are particularly attractive due to their high availability, as well as immune-privileged status. However, it is still unclear whether mesenchymal stem cells can acquire cardiomyogenic characteristics after they are transplanted to the myocardium. In this article, we outline protocols that illustrate the plasticity of MSCs and their ability to acquire cardiogenic characteristics when they are in an ischemic-like environment, as typically encountered after transplantation into the ischemic heart.

Original languageEnglish (US)
Article numbere62
JournalCurrent Protocols
Issue number3
StatePublished - Mar 2021


  • cardiogenic
  • luciferase
  • mesenchymal stem cells
  • neonatal cardiomyocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Health Informatics
  • Medical Laboratory Technology
  • Medicine(all)


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