Abstract
Cell therapy is being investigated as a powerful intervention to ameliorate the consequences of coronary artery disease. Among the different stem cell options, mesenchymal stem cells (MSCs) are particularly attractive due to their high availability, as well as immune-privileged status. However, it is still unclear whether mesenchymal stem cells can acquire cardiomyogenic characteristics after they are transplanted to the myocardium. In this article, we outline protocols that illustrate the plasticity of MSCs and their ability to acquire cardiogenic characteristics when they are in an ischemic-like environment, as typically encountered after transplantation into the ischemic heart.
| Original language | English (US) |
|---|---|
| Article number | e62 |
| Journal | Current Protocols |
| Volume | 1 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2021 |
Keywords
- cardiogenic
- luciferase
- mesenchymal stem cells
- neonatal cardiomyocytes
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Neuroscience(all)
- Immunology and Microbiology(all)
- Health Informatics
- Medical Laboratory Technology
- Medicine(all)