Cardiac pathology in status epilepticus

Edward M. Manno, Eric A. Pfeifer, Gregory D. Cascino, Katherine H. Noe, Eelco F.M. Wijdicks

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Massive catecliolamine release resulting in the formation of cardiac contraction bands may represent die cause of death in status epilepticus (SE). We reviewed die cardiac pathology of patients who died during SE to asses for contraction bands. Eight of 11 patients who died during SE had identifiable myocardial contraction bands compared with 5 of 22 control patients (p < 0.05, Fisher's exact t test). These findings delineate a pathological substrate and provide compelling evidence that excessive catecholamine release is the mechanism responsible for death in SE.

Original languageEnglish (US)
Pages (from-to)954-957
Number of pages4
JournalAnnals of neurology
Issue number6
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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