Cardiac magnetic resonance imaging of eosinophilic endomyocardial disease

Imran S. Syed, Matthew W. Martinez, Da Li Feng, James F. Glockner

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Idiopathic hypereosinophilic syndrome (HES) is rare and frequently involves the heart with development of endomyocardial fibrosis, a characteristic restrictive cardiomyopathy. Non-invasive diagnosis is frequently challenging. Recent developments in cardiac magnetic resonance (CMR) imaging techniques offer potential for improved detection and characterization of this entity. We describe the use of contrast-enhanced CMR to demonstrate thrombus, endomyocardial fibrosis and inflammation in eosinophilic endomyocardial disease. A three-layered appearance consisting of normal myocardium, thickened fibrotic endocardium with inflammatory exudate, and overlying thrombus was seen on cine-images. Post-contrast perfusion and delayed enhancement images confirmed the presence and location of endomyocardial fibrosis and thrombus. CMR is an important and powerful addition to current non-invasive diagnostic tools for the clinical diagnosis of eosinophilic endomyocardial disease, and may potentially obviate the need for cardiac biopsy in the future.

Original languageEnglish (US)
Pages (from-to)e50-e52
JournalInternational Journal of Cardiology
Issue number3
StatePublished - Jun 6 2008


  • Endomyocardial fibrosis
  • Hypereosinophilic syndrome
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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