Cardiac channelopathies: It's in the genes

Research output: Contribution to journalShort surveypeer-review

132 Scopus citations


In 1995, Mark Keating and colleagues identified two genes responsible for congenital long QT syndrome, a cause of sudden cardiac death. Perturbations in the ion channels that orchestrate the beating heart were central to the disorder. This revelation provided a molecular model for the study of ventricular arrhythmias and enabled further dissection of the genetic defects underlying subtleties in the cardiac phenotype. Soon, these discoveries will be further translated to clinical medicine, with the expected release of one of the first comprehensive clinical genetic tests in cardiology.

Original languageEnglish (US)
Pages (from-to)463-464
Number of pages2
JournalNature Medicine
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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