Cardiac Amyloidosis

Marinos C. Dalakas; M. A. Gertz; L. J. Olson; W. D. Edwards; C. Y. li; P. A. Pellikka; D. R. Holmes; A. J. Tajik; Robert A. Kyle

doi:10.1056/NEJM198803103181015

Cardiac Amyloidosis

Marinos C. Dalakas, M. A. Gertz, L. J. Olson, W. D. Edwards, C. Y. li, P. A. Pellikka, D. R. Holmes, A. J. Tajik, Robert A. Kyle

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: The effort by Olson et al. (Sept. 17 issue)¹ to characterize deposits of cardiac amyloid is identical to our work on the characterization of amyloid deposits in muscle and nerve biopsy specimens from patients with amyloid polyneuropathy of the “sporadic” type²³⁴ (the nonfamilial, nonsecretory immunoglobulin-derived amyloid). The study is also relevant to ours because in amyloid polyneuropathy the heart is involved by amyloid. I have concerns, however, about the specificity of the staining with the antiserums used. After 10 years of experience with the immunohistochemistry of amyloid, we have found that immunostaining is not as simple as.

Original language	English (US)
Pages (from-to)	641-642
Number of pages	2
Journal	New England Journal of Medicine
Volume	318
Issue number	10
DOIs	https://doi.org/10.1056/NEJM198803103181015
State	Published - Mar 10 1988

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Medicine(all)

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title = "Cardiac Amyloidosis",

abstract = "To the Editor: The effort by Olson et al. (Sept. 17 issue)1 to characterize deposits of cardiac amyloid is identical to our work on the characterization of amyloid deposits in muscle and nerve biopsy specimens from patients with amyloid polyneuropathy of the “sporadic” type234 (the nonfamilial, nonsecretory immunoglobulin-derived amyloid). The study is also relevant to ours because in amyloid polyneuropathy the heart is involved by amyloid. I have concerns, however, about the specificity of the staining with the antiserums used. After 10 years of experience with the immunohistochemistry of amyloid, we have found that immunostaining is not as simple as.",

author = "Dalakas, {Marinos C.} and Gertz, {M. A.} and Olson, {L. J.} and Edwards, {W. D.} and li, {C. Y.} and Pellikka, {P. A.} and Holmes, {D. R.} and Tajik, {A. J.} and Kyle, {Robert A.}",

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T1 - Cardiac Amyloidosis

AU - Dalakas, Marinos C.

AU - Gertz, M. A.

AU - Olson, L. J.

AU - Edwards, W. D.

AU - li, C. Y.

AU - Pellikka, P. A.

AU - Holmes, D. R.

AU - Tajik, A. J.

AU - Kyle, Robert A.

PY - 1988/3/10

Y1 - 1988/3/10

N2 - To the Editor: The effort by Olson et al. (Sept. 17 issue)1 to characterize deposits of cardiac amyloid is identical to our work on the characterization of amyloid deposits in muscle and nerve biopsy specimens from patients with amyloid polyneuropathy of the “sporadic” type234 (the nonfamilial, nonsecretory immunoglobulin-derived amyloid). The study is also relevant to ours because in amyloid polyneuropathy the heart is involved by amyloid. I have concerns, however, about the specificity of the staining with the antiserums used. After 10 years of experience with the immunohistochemistry of amyloid, we have found that immunostaining is not as simple as.

AB - To the Editor: The effort by Olson et al. (Sept. 17 issue)1 to characterize deposits of cardiac amyloid is identical to our work on the characterization of amyloid deposits in muscle and nerve biopsy specimens from patients with amyloid polyneuropathy of the “sporadic” type234 (the nonfamilial, nonsecretory immunoglobulin-derived amyloid). The study is also relevant to ours because in amyloid polyneuropathy the heart is involved by amyloid. I have concerns, however, about the specificity of the staining with the antiserums used. After 10 years of experience with the immunohistochemistry of amyloid, we have found that immunostaining is not as simple as.

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Cardiac Amyloidosis

Abstract

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