Carbohydrate Metabolism in Non-Insulin-Dependent Diabetes Mellitus

Jeffrey S. Flier, Lisa H. Underhill, Sean Dinneen, John Gerich, Robert Rizza

Research output: Contribution to journalReview articlepeer-review

252 Scopus citations


DIABETES mellitus is characterized by both fasting hyperglycemia and exaggerated postprandial increases in the plasma glucose level. Understanding the causes of these abnormalities is important for the rational use of current treatments and for developing more effective therapy. In this seminar, we review the physiology of normal carbohydrate metabolism and the pathophysiology of abnormalities in diabetes mellitus. Normal Physiology: Postabsorptive State The term “postabsorptive state” refers to the period 6 to 12 hours after a meal during which the transition from the postprandial to the fasting state occurs. At this time plasma glucose levels are at a nearly steady state;…

Original languageEnglish (US)
Pages (from-to)707-713
Number of pages7
JournalNew England Journal of Medicine
Issue number10
StatePublished - Sep 3 1992

ASJC Scopus subject areas

  • Medicine(all)


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