Carbohydrate metabolism and the skeleton: Picking a bone with the β-cell

Research output: Contribution to journalComment/debatepeer-review

11 Scopus citations


Novel data show that the bone protein, undercarboxylated osteocalcin, increases islet cell growth and insulin and adiponectin synthesis and enhances glucose metabolism in mice. Human studies, in which undercarboxylated osteocalcin concentrations have been perturbed, show no effect (or a very minor effect) on fasting glucose or insulin concentrations. More extensive and detailed experiments in humans are needed to definitively establish the role of undercarboxylated osteocalcin in human carbohydrate metabolism.

Original languageEnglish (US)
Pages (from-to)1269-1271
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number5
StatePublished - May 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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