Captopril and Renal Insufficiency

Yves Pirson, Martine de Meyer, Jean François de Plaen, Jean Paul Squifflet, Guy P. Alexandre, Charles Ypersele Van de Strihou, Karl A. Nath, Arthur J. Crumbley, Brian M. Murray, Richard K. Sibley, J. A. Whitworth, P. S. Kincaid-Smith, John J. Curtis, Robert G. Luke, John D. Whelchel, Arnold G. Diethelm, Patricia Jones, Harriet P. Dustan, Richard I. Kopelman, Donald E. HricikWarren E. Goorno, Nicolaos E. Madias, Victor J. Dzau, Philip J. Browning

Research output: Contribution to journalLetterpeer-review

14 Scopus citations


To the Editor: Curtis et al. reported captopril-induced functional renal insufficiency in four transplant recipients with hypertension and graft-artery stenosis (Feb. 17 issue).* No such changes were observed after captopril administration in hypertensive transplant recipients without graft-artery stenosis. The authors thus suggest that captopril could be used as a diagnostic test to detect artery stenosis in hypertensive graft recipients. Our own data support their conclusion that captopril-induced renal failure in transplant recipients is suggestive of graft-artery stenosis. These data provide further evidence that in these cases the graft-artery stenosis is the cause of hypertension. Over the past two years we.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalNew England Journal of Medicine
Issue number11
StatePublished - Sep 15 1983

ASJC Scopus subject areas

  • Medicine(all)


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