TY - JOUR
T1 - Cancer risk after evaluation for infertility
AU - Brinton, Louise A.
AU - Melton, L. Joseph
AU - Malkasian, George D.
AU - Bond, Annell
AU - Hoover, Robert
N1 - Funding Information:
Abbreviation: SIR, standardized incidence ratio. ' Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD. Department of Health Sciences Research, Mayo Clinic Rochester MN * Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN. " Westat, Inc., RockviUe, MD. Reprint requests to Dr. Louise A. Brinton, Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892. This study was supported in part by Contract NOi-CP-11023 from the National Cancer Institute, NIH.
PY - 1989/4
Y1 - 1989/4
N2 - To evaluate cancer risk by various causes of infertility, the authors conducted a retrospective cohort study among 2, 335 women evaluated for infertility at the Mayo Clinic between 1935 and 1964. Most cancers occurred at expected fre quencies, with the exception of cancers of the thyroid (standardized incidence ratio (SIR) = 2.6) and other endocrine glands (SIR = 6.7), although analyses were based on small numbers. Patients with progesterone deficIencies (31 per cent of the study subjects) had a 20 per cent higher cancer risk than did those with other causes of infertility, with excesses deriving primarily from cancers of the lung, cervix, ovary, and thyroid and from melanoma. Breast cancer risk, however, was not elevated in either patients with progesterone deficiencies (SIR = 0.9) or patients with other causes of infertility (SIR = 1.0). Examination of other pararn eters of infertility, including age at evaluation, type of infertity (primary vs. secondary), and years of attempted conception, showed no elevated risks of breast cancer in any subgroup. These results fail to support previous studies that have linked progesterone deficiencies among infertile women to elevated breast cancer risk. However, the data suggest a possible involvement of a progesterone deficiency In the etiology of other cancers, particularly thyroid cancer and mela noma.
AB - To evaluate cancer risk by various causes of infertility, the authors conducted a retrospective cohort study among 2, 335 women evaluated for infertility at the Mayo Clinic between 1935 and 1964. Most cancers occurred at expected fre quencies, with the exception of cancers of the thyroid (standardized incidence ratio (SIR) = 2.6) and other endocrine glands (SIR = 6.7), although analyses were based on small numbers. Patients with progesterone deficIencies (31 per cent of the study subjects) had a 20 per cent higher cancer risk than did those with other causes of infertility, with excesses deriving primarily from cancers of the lung, cervix, ovary, and thyroid and from melanoma. Breast cancer risk, however, was not elevated in either patients with progesterone deficiencies (SIR = 0.9) or patients with other causes of infertility (SIR = 1.0). Examination of other pararn eters of infertility, including age at evaluation, type of infertity (primary vs. secondary), and years of attempted conception, showed no elevated risks of breast cancer in any subgroup. These results fail to support previous studies that have linked progesterone deficiencies among infertile women to elevated breast cancer risk. However, the data suggest a possible involvement of a progesterone deficiency In the etiology of other cancers, particularly thyroid cancer and mela noma.
KW - Breast neoplasms
KW - Infertility
KW - Neoplasms
KW - Risk
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U2 - 10.1093/oxfordjournals.aje.a115186
DO - 10.1093/oxfordjournals.aje.a115186
M3 - Article
C2 - 2923119
AN - SCOPUS:0024477561
SN - 0002-9262
VL - 129
SP - 712
EP - 722
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 4
ER -