Cancer progression modeling using static sample data

Yijun Sun, Jin Yao, Norma J. Nowak, Steve Goodison

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


As molecular profiling data continues to accumulate, the design of integrative computational analyses that can provide insights into the dynamic aspects of cancer progression becomes feasible. Here, we present a novel computational method for the construction of cancer progression models based on the analysis of static tumor samples. We demonstrate the reliability of the method with simulated data, and describe the application to breast cancer data. Our findings support a linear, branching model for breast cancer progression. An interactive model facilitates the identification of key molecular events in the advance of disease to malignancy.

Original languageEnglish (US)
Article number440
Pages (from-to)440
Number of pages1
JournalGenome biology
Issue number8
StatePublished - 2014

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology


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