Cancer gene therapy: Developments to 2000

A. R. Bateman, K. J. Harrington, A. A. Melcher, R. G. Vile

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Cancer, at the molecular level, continues to be more thoroughly understood. With this understanding comes the opportunity for innovative therapeutic intervention. Gene therapy remains an attractive concept to treat cancer. However, a number of gene therapy clinical trials have now been reported and it is clear that barriers remain before gene therapy gains widespread clinical application. This article outlines current directions and novel developments in the field of cancer gene therapy, which attempt to overcome these obstacles.

Original languageEnglish (US)
Pages (from-to)2799-2813
Number of pages15
JournalExpert Opinion on Investigational Drugs
Issue number12
StatePublished - 2000


  • Anti-angiogenesis
  • Cancer
  • Gene therapy
  • Immunotherapy
  • Replication-competent vector
  • Review
  • Suicide gene
  • Targeting
  • Viral vector

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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