Can loratadine help in treating granulocyte-colony stimulating factor-induced bone pain?

Shilpa N. Gajarawala, Jessica N. Pelkowski, Christopher C. Destephano

Research output: Contribution to journalArticlepeer-review


Febrile neutropenia is an oncologic emergency with serious consequences. Granulocyte colony stimulating factors (G-CSFs), used to stimulate neutrophil production to prevent febrile neutropenia, can cause bone pain in more than 25% of patients. Severe bone pain may not respond to acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, or dose reduction of the G-CSF agent. A study found that patients taking loratadine had fewer treatment-associated adverse reactions and discontinuations than those on naproxen. Although more research is needed, loratadine's tolerability, ease of administration, and potential benefit mean that it should be considered for management of pegfilgrastim-associated bone pain. This article describes a patient whose G-CSF-induced bone pain was completely alleviated by loratadine.

Original languageEnglish (US)
Pages (from-to)29-31
Number of pages3
JournalJournal of the American Academy of Physician Assistants
Issue number7
StatePublished - Jul 1 2021


  • antihistamine
  • bone pain
  • filgrastim
  • granulocyte colony stimulating factor
  • loratadine
  • pegfilgrastim

ASJC Scopus subject areas

  • Nurse Assisting


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