Can genes for mammographic density inform cancer aetiology?

Linda E. Kelemen, Thomas A. Sellers, Celine M. Vachon

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Mammographic density (MD) reflects variations in fat, stromal and epithelial tissues that are thought to be regulated by several genes. High MD is an established risk factor for breast cancer; therefore, genes that regulate MD may indirectly influence breast cancer. These genes might also be fewer in number and easier to identify than those for breast cancer risk outside of inherited predisposition syndromes. In this Perspective, we review the limited genetic studies of MD and propose future directions.

Original languageEnglish (US)
Pages (from-to)812-823
Number of pages12
JournalNature Reviews Cancer
Issue number10
StatePublished - Oct 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Can genes for mammographic density inform cancer aetiology?'. Together they form a unique fingerprint.

Cite this