Calf vein thrombosis outcomes comparing patients with and without cancer

Ahmed K. Pasha, Wiktoria Kuczmik, Waldemar E. Wysokinski, Ana I. Casanegra, Damon Houghton, Danielle T. Vlazny, Abigail Mertzig, Yumiko Hirao-Try, Launia White, David Hodge, Robert McBane

Research output: Contribution to journalArticlepeer-review


Distal or calf deep vein thrombosis (DVT) are said to have low rates of propagation, embolization, and recurrence. The objective of this study was to determine outcomes among cancer patients with calf DVT compared to those without cancer. Consecutive patients with ultrasound confirmed acute calf DVT (3/1/2013–8/10/2019) were assessed for venous thromboembolism (VTE) recurrence and bleeding outcomes compared by cancer status. There were 830 patients with isolated calf DVT; 243 with cancer and 587 without cancer. Cancer patients were older (65.9 ± 11.4 vs. 62.0 ± 15.9 years; p = 0.006), with less frequent recent hospitalization (31.7% vs. 48.0%; p < 0.001), surgery (30.0% vs. 38.0%; p = 0.03), or trauma (3.7% vs. 19.9%; p < 0.001). The four most common cancers included hematologic malignancies (20.6%), lung (11.5%), gastrointestinal (10.3%), and ovarian/GYN (9.1%). Nearly half of patients had metastatic disease (43.8%) and 57% were receiving chemotherapy. VTE recurrence rates were similar for patients with (7.1%) and without cancer (4.0%; p = 0.105). Major bleeding (6.3% vs. 2.3%; p = 0.007) were greater for cancer patients while clinical relevant non major bleeding rates did not differ (7.1% vs. 4.6%; p = 0.159). In this retrospective analysis, cancer patients with calf DVT have similar rates of VTE recurrence but higher major bleeding outcomes compared to patients without cancer.

Original languageEnglish (US)
Pages (from-to)1059-1066
Number of pages8
JournalJournal of Thrombosis and Thrombolysis
Issue number4
StatePublished - May 2021


  • Calf deep vein thrombosis
  • Cancer
  • Distal deep vein thrombosis
  • Major bleeding
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine


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