C-reactive protein among community-dwelling hypertensives on single-agent antihypertensive treatment

Tibor Fulop, Andrew D. Rule, Darren W. Schmidt, Heather J. Wiste, Kent R. Bailey, Iftikhar J. Kullo, Gary L. Schwartz, Thomas H. Mosley, Eric Boerwinkle, Stephen T. Turner

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


C-reactive protein (CRP) is a predictor of adverse cardiovascular outcomes. The effect of antihypertensive therapy on CRP levels is largely unknown. We undertook a cross-sectional study of CRP levels among participants with primary hypertension on single-agent antihypertensive therapy in the community-based biracial Genetic Epidemiology Network of Arteriopathy cohort. Linear regression models were used to assess the association of antihypertensive medication class with log-transformed CRP after adjustment for age, gender, ethnicity, body mass index, smoking, diabetes, hydroxymethylglutaryl CoA reductase inhibitor use, achieved blood pressure control (<140/90 mm Hg), serum creatinine and urine albumin-to-creatinine ratios. There were 662 participants in the cohort taking single-agent therapy for hypertension. Median CRP levels differed across participants: 0.40 mg/dL for those on diuretics, 0.34 mg/dL on calcium-channel blockers, 0.25 mg/dL on beta-blockers and 0.27 mg/dL on renin-angiotensin-aldosterone system (RAAS) inhibitors (P < .001). With multivariable adjustment, the group on RAAS inhibitors had a 20% lower mean CRP on average than the group on diuretics (P = .044), differences between other medication classes were not apparent. Heart rate had a strong association with CRP (P < .001). Antihypertensive medication class may influence inflammation, particularly in patients on RAAS inhibitors.

Original languageEnglish (US)
Pages (from-to)260-266
Number of pages7
JournalJournal of the American Society of Hypertension
Issue number4
StatePublished - Jul 2009


  • Diuretics
  • RAAS inhibitors
  • inflammation
  • sibships

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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