@inproceedings{8ea72fce69ec4d4ebdf4b372e2d896fc,
title = "Burn, freeze or photo-ablate? Comparative symptom profile in Barrett's dysplasia patients undergoing endoscopic ablation",
abstract = "Background: There are few data available comparing endoscopic ablation methods for Barrett's esophagus with high-grade dysplasia (BE-HGD). Objective: To determine differences in symptoms and complications associated with endoscopic ablation. Design: Prospective observational study. Setting: Two tertiary care centers in USA. Patients: Consecutive patients with BE-HGD Interventions: In this pilot study, symptoms profile data were collected for BE-HGD patients among 3 endoscopic ablation methods: porfimer sodium photodynamic therapy, radiofrequency ablation and low-pressure liquid nitrogen spray cryotherapy. Main Outcome Measurements: Symptom profiles and complications from the procedures were assessed 1-8 weeks after treatment. Results: Ten BE-HGD patients were treated with each ablation modality (30 patients total; 25 men, median age: 69 years (range 53-81). All procedures were performed in the clinic setting and none required subsequent hospitalization. The most common symptoms among all therapies were chest pain, dysphagia and odynophagia. More patients (n=8) in the porfimer sodium photodynamic therapy group reported weight loss compared to radio-frequency ablactation (n=2) and cryotherapy (n=0). Four patients in the porfimer sodium photodynamic therapy group developed phototoxicity requiring medical treatment. Strictures, each requiring a single dilation, were found in radiofrequency ablactation (n=1) and porfimer sodium photodynamic therapy (n=2) patients. Limitations: Small sample size, non-randomized study. Conclusions: These three endoscopic therapies are associated with different types and severity of post-ablation symptoms and complications.",
keywords = "Barrett's esophagus, cryotherapy, photodynamic therapy, radiofrequency ablation",
author = "Gill, {Kanwar Rupinder S.} and Gross, {Seth A.} and Greenwald, {Bruce D.} and Hemminger, {Lois L.} and Wolfsen, {Herbert C.}",
year = "2009",
doi = "10.1117/12.822827",
language = "English (US)",
isbn = "9780819476609",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "12th World Congress of the International Photodynamic Association - Photodynamic Therapy",
note = "12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future ; Conference date: 11-06-2009 Through 15-06-2009",
}