Burden of disease progression in patients with multiple myeloma in the US

May Hagiwara, Sumeet Panjabi, Tom Delea, Emre Yucel, Rafael Fonseca

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Effects of disease progression on healthcare resource utilization (HRU) and costs among multiple myeloma (MM) patients with ≥1 line of therapy (LOT) and without receipt of stem cell transplant were estimated using large US claims database. Disease progression was defined as advancement to the next LOT, bone metastasis, hypercalcemia, soft tissue plasmacytoma, skeletal related events, acute kidney failure, or death within 12 months of LOT initiation. Annual HRU and costs in the first four LOTs were compared for patients with versus without progression using inverse probability of treatment weighting to adjust for differences between groups in baseline characteristics. In all LOTs, mean annual hospitalizations and healthcare costs were greater for patients with versus without progression. Total incremental annual costs among patients with versus without progression in 1LOT to 4LOT were $25,920, $30,632, $47,320, and $19,769, respectively. For MM patients receiving drug therapy, the economic burden of disease progression is substantial.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalLeukemia and Lymphoma
Issue number1
StatePublished - Jan 2 2020


  • Multiple myeloma
  • disease progression
  • healthcare costs
  • retrospective study

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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