Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

HPB Organoid Consortium

doi:10.1016/j.stem.2021.04.005

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

HPB Organoid Consortium

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

Abstract

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.

Original language	English (US)
Pages (from-to)	816-832
Number of pages	17
Journal	Cell Stem Cell
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2021.04.005
State	Published - May 6 2021

Keywords

Delphi method
HPB
bile duct
epithelial organoid
gallbladder
liver
multi-organ organoid
multi-tissue organoid
pancreas
tumor organoid

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2021.04.005

Cite this

@article{a0bd42362b22437ea380567dcc0b79f8,

title = "Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids",

abstract = "Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.",

keywords = "Delphi method, HPB, bile duct, epithelial organoid, gallbladder, liver, multi-organ organoid, multi-tissue organoid, pancreas, tumor organoid",

author = "{HPB Organoid Consortium} and Ary Marsee and Roos, {Floris J.M.} and Verstegen, {Monique M.A.} and Floris Roos and Monique Verstegen and Hans Clevers and Ludovic Vallier and Takanori Takebe and Meritxell Huch and Peng, {Weng Chuan} and Stuart Forbes and Fr{\'e}d{\'e}ric Lemaigre and {de Koning}, Eelco and Helmuth Gehart and Bart Spee and Sylvia Boj and Pedro Baptista and Kerstin Schneeberger and Carol Soroka and Markus Heim and Sandro Nuciforo and Kenneth Zaret and Yoshimasa Saito and Matthias Lutolf and Vincenzo Cardinale and Ben Simons and {van IJzendoorn}, Sven and Akihide Kamiya and Hiromi Chikada and Shuyong Wang and Mun, {Seon Ju} and Son, {Myung Jin} and Onder, {Tamer Tevfik} and James Boyer and Toshiro Sato and Nikitas Georgakopoulos and Andre Meneses and Laura Broutier and Luke Boulter and Dominic Gr{\"u}n and Jan IJzermans and Benedetta Artegiani and {van Boxtel}, Ruben and Ewart Kuijk and Guido Carpino and Gary Peltz and Jesus Banales and Nancy Man and Luigi Aloia and Nicholas LaRusso",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = may,

day = "6",

doi = "10.1016/j.stem.2021.04.005",

language = "English (US)",

volume = "28",

pages = "816--832",

journal = "Cell Stem Cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "5",

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TY - JOUR

T1 - Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

AU - HPB Organoid Consortium

AU - Marsee, Ary

AU - Roos, Floris J.M.

AU - Verstegen, Monique M.A.

AU - Roos, Floris

AU - Verstegen, Monique

AU - Clevers, Hans

AU - Vallier, Ludovic

AU - Takebe, Takanori

AU - Huch, Meritxell

AU - Peng, Weng Chuan

AU - Forbes, Stuart

AU - Lemaigre, Frédéric

AU - de Koning, Eelco

AU - Gehart, Helmuth

AU - Spee, Bart

AU - Boj, Sylvia

AU - Baptista, Pedro

AU - Schneeberger, Kerstin

AU - Soroka, Carol

AU - Heim, Markus

AU - Nuciforo, Sandro

AU - Zaret, Kenneth

AU - Saito, Yoshimasa

AU - Lutolf, Matthias

AU - Cardinale, Vincenzo

AU - Simons, Ben

AU - van IJzendoorn, Sven

AU - Kamiya, Akihide

AU - Chikada, Hiromi

AU - Wang, Shuyong

AU - Mun, Seon Ju

AU - Son, Myung Jin

AU - Onder, Tamer Tevfik

AU - Boyer, James

AU - Sato, Toshiro

AU - Georgakopoulos, Nikitas

AU - Meneses, Andre

AU - Broutier, Laura

AU - Boulter, Luke

AU - Grün, Dominic

AU - IJzermans, Jan

AU - Artegiani, Benedetta

AU - van Boxtel, Ruben

AU - Kuijk, Ewart

AU - Carpino, Guido

AU - Peltz, Gary

AU - Banales, Jesus

AU - Man, Nancy

AU - Aloia, Luigi

AU - LaRusso, Nicholas

PY - 2021/5/6

Y1 - 2021/5/6

N2 - Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.

AB - Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.

KW - Delphi method

KW - HPB

KW - bile duct

KW - epithelial organoid

KW - gallbladder

KW - liver

KW - multi-organ organoid

KW - multi-tissue organoid

KW - pancreas

KW - tumor organoid

UR - http://www.scopus.com/inward/record.url?scp=85105055143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85105055143&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2021.04.005

DO - 10.1016/j.stem.2021.04.005

M3 - Review article

AN - SCOPUS:85105055143

SN - 1934-5909

VL - 28

SP - 816

EP - 832

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 5

ER -

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Abstract

Keywords

ASJC Scopus subject areas

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