Broken-hearted women: The complex relationship between depression and cardiovascular disease

Sharonne N. Hayes

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


The importance of mind-body health relationships has been recognized for decades, but only recently has the wider medical and cardiovascular community become engaged in understanding and addressing the complex, bidirectional risk relationship between cardiovascular disease (CVD) and depression. Furthermore, it has become increasingly clear that there are incompletely understood sex differences in incidence and outcomes for both conditions that should guide treatment and future research efforts. This review will explore the role of depression in women as a risk factor for incident CVD, its impact on women already suffering from CVD, proposed psychobiologic mechanisms and links, and the implications of sex differences on diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)709-725
Number of pages17
JournalWomen's Health
Issue number6
StatePublished - 2009


  • Antidepressant
  • Cardiovascular disease
  • Cognitive behavioral therapy
  • Depression
  • Heart disease
  • Selective serotonin release inhibitors
  • Sex-specific results
  • Women

ASJC Scopus subject areas

  • Medicine(all)


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