Breast manifestations of systemic diseases

Christina A. Dilaveri, Maire Brid Macbride, Nicole P. Sandhu, Lonzetta Neal, Karthik Ghosh, Dietlind L. Wahner-Roedler

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Although much emphasis has been placed on the primary presentations of breast cancer, little focus has been placed on how systemic illnesses may affect the breast. In this article, we discuss systemic illnesses that can manifest in the breast. We summarize the clinical features, imaging, histopathology, and treatment recommendations for endocrine, vascular, systemic inflammatory, infectious, and hematologic diseases, as well as for the extramammary malignancies that can present in the breast. Despite the rarity of these manifestations of systemic disease, knowledge of these conditions is critical to the appropriate evaluation and treatment of patients presenting with breast symptoms.

Original languageEnglish (US)
Pages (from-to)35-43
Number of pages9
JournalInternational Journal of Women's Health
Issue number1
StatePublished - Feb 4 2012


  • Breast
  • Endocrine
  • Hematologic
  • Infectious
  • Vascular

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology
  • Maternity and Midwifery


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