Breast cancer in adolescents and young adults

Rebecca H. Johnson, Carey K. Anders, Jennifer K. Litton, Kathryn J. Ruddy, Archie Bleyer

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Breast cancer is the most common cancer of adolescents and young adult (AYA) women aged 15 to 39 years, accounting for 5.6% of all invasive breast cancer in women. In comparison with older women, AYAs are more likely to have familial cancer predisposition genes, larger breast tumors, unfavorable biological characteristics, distant metastatic disease at diagnosis, and adverse outcome. Endocrine therapy and some chemotherapy recommendations differ between young and older women. AYAs require coordinated multidisciplinary care, treatment regimens that minimize late effects such as premature menopause and osteoporosis, and proactive management of psychological and sexual health during and after cancer treatment.

Original languageEnglish (US)
Article numbere27397
JournalPediatric Blood and Cancer
Issue number12
StatePublished - Dec 2018


  • age
  • breast
  • neoplasm
  • pregnancy
  • young adult

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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