Breast cancer in a transgender woman undergoing gender-affirming exogenous hormone therapy

Michael D. Villalba; Haley P. Letter; Kristin A. Robinson; Santo Maimone

doi:10.1016/j.radcr.2023.04.032

Breast cancer in a transgender woman undergoing gender-affirming exogenous hormone therapy

Michael D. Villalba, Haley P. Letter, Kristin A. Robinson, Santo Maimone

Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

Gender-affirming hormone therapy may be utilized by transgender women hoping to induce feminizing changes and suppress the effects of endogenous testosterone. It is well established that exogenous hormone use increases risk of breast cancer in cisgender women; however, a link in the transgender population is less clear. Our case presents a transgender woman undergoing gender-affirming exogenous hormone therapy who subsequently developed breast cancer. We review the available literature regarding risks of exogenous hormone therapy with regards to breast cancer development. Additionally, we present current societal guidelines and recommendations for screening in this population.

Original language	English (US)
Pages (from-to)	2511-2513
Number of pages	3
Journal	Radiology Case Reports
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/j.radcr.2023.04.032
State	Published - Jul 2023

Keywords

Breast cancer
Hormone therapy
MRI
Male-to-female
Mammography
Transgender

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.radcr.2023.04.032

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title = "Breast cancer in a transgender woman undergoing gender-affirming exogenous hormone therapy",

abstract = "Gender-affirming hormone therapy may be utilized by transgender women hoping to induce feminizing changes and suppress the effects of endogenous testosterone. It is well established that exogenous hormone use increases risk of breast cancer in cisgender women; however, a link in the transgender population is less clear. Our case presents a transgender woman undergoing gender-affirming exogenous hormone therapy who subsequently developed breast cancer. We review the available literature regarding risks of exogenous hormone therapy with regards to breast cancer development. Additionally, we present current societal guidelines and recommendations for screening in this population.",

keywords = "Breast cancer, Hormone therapy, MRI, Male-to-female, Mammography, Transgender",

author = "Villalba, {Michael D.} and Letter, {Haley P.} and Robinson, {Kristin A.} and Santo Maimone",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

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AB - Gender-affirming hormone therapy may be utilized by transgender women hoping to induce feminizing changes and suppress the effects of endogenous testosterone. It is well established that exogenous hormone use increases risk of breast cancer in cisgender women; however, a link in the transgender population is less clear. Our case presents a transgender woman undergoing gender-affirming exogenous hormone therapy who subsequently developed breast cancer. We review the available literature regarding risks of exogenous hormone therapy with regards to breast cancer development. Additionally, we present current societal guidelines and recommendations for screening in this population.

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KW - Hormone therapy

KW - MRI

KW - Male-to-female

KW - Mammography

KW - Transgender

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Breast cancer in a transgender woman undergoing gender-affirming exogenous hormone therapy

Abstract

Keywords

ASJC Scopus subject areas

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