Breast Benign and Malignant Tumors Rapidly Screening by ARFI-VTI Elastography and Random Decision Forests Based Classifier

Jian Xing Wu, Pi Yun Chen, Chia Hung Lin, Shigao Chen, K. Kirk Shung

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Breast cancer is the most common cancer among women in Taiwan, and the number of breast cancer cases reported annually continues to increase. In 2018, breast cancer ranked fourth in terms of mortality. Early stages (stages 0-2) of malignant breast lesions can be diagnosed during regular screening, and early treatment via advanced medical therapies increases survival rates. Ultrasound imaging, including acoustic radiation force impulse (ARFI) imaging, is the first-line examination technique used to locate breast lesion tissue, which can then be quantitated by virtual touch tissue imaging (VTI). ARFI-VTI elastography is a breast imaging modality that creates two-dimensional (2D) images to visualize the texture details, elasticity, and morphological features of a region of interest (ROI). The 2D Harris corner convolution is applied during digital imaging to remove speckle noise and enhance the ARFI-VTI images for extrapolation of lesion tissue in a ROI. Then, 2D Harris corner convolution, maximum pooling, and random decision forests (RDF) are integrated into a machine vision classifier to screen subjects with benign or malignant tumors. A total of 320 ARFI-VTI images were collected for experiments. In training stages, 122 images were randomly selected to train the RDF-based classifiers and the remaining images were randomly selected for performance evaluation via cross-validation in recalling stages. In a 10-fold cross-validation, promising results with mean sensitivity, mean specificity, and mean accuracy of 86.02%, 87.63%, and 86.97%, respectively, are achieved for quantifying the performance of the proposed classifier. Breast tumors visualized on ARFI-VTI images can be used for rapid screening of malignant or benign lesions by using the proposed machine vision classifier.

Original languageEnglish (US)
Article number9034024
Pages (from-to)54019-54034
Number of pages16
JournalIEEE Access
StatePublished - 2020


  • Acoustic radiation force impulse
  • elastography
  • harris corner convolution
  • random decision forest
  • virtual touch tissue imaging

ASJC Scopus subject areas

  • General Computer Science
  • General Materials Science
  • General Engineering


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