Abstract
BACKGROUND AND PURPOSE: The objective of this study was to longitudinally investigate the trajectory of change in 1H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the neurochemical alterations accelerated during disease progression. METHODS: We identified eight MAPT mutations carriers who transitioned from asymptomatic to symptomatic disease during follow-up. All participants were longitudinally followed with an average of 7.75 years (range 4-11 years) and underwent two or more single voxel 1H MRS examinations from the posterior cingulate voxel, with a total of 60 examinations. The rate of longitudinal change for each metabolite was estimated using linear mixed models. A flex point model was used to estimate the flex time point of the change in slope. RESULTS: The decrease in the NAA/mI ratio accelerated 2.09 years prior to symptom onset, and continued to decline. A similar trajectory was observed in the presumed glial marker mI/Cr ratio accelerating 1.86 years prior to symptom onset. CONCLUSIONS: Our findings support the potential use of longitudinal 1H MRS for monitoring the neurodegenerative progression in MAPT mutation carriers starting from the asymptomatic stage.
Original language | English (US) |
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Pages (from-to) | 624-629 |
Number of pages | 6 |
Journal | Journal of Neuroimaging |
Volume | 29 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1 2019 |
Keywords
- MAPT
- MRS
- converter
- frontotemporal lobar degeneration
- longitudinal
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology