Brain morphometry changes and depressive symptoms after traumatic brain injury

Anne Hudak, Matthew Warner, Carlos Marquez de la Plata, Carol Moore, Caryn Harper, Ramon Diaz-Arrastia

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Traumatic brain injury (TBI) is associated with an increased risk of depressive symptoms. Recent imaging studies on spontaneous depression have implicated several brain structures; however, few studies have done the same for post-TBI depression. We report on a pilot observational study correlating atrophy of brain regions of interest in subjects after TBI with depressive symptoms measured by the Beck Depression Inventory-II. Regional brain volumes were calculated on both acute and 6-month MRI using an automated segmentation algorithm (FreeSurfer). Percent volume changes in brain regions were correlated with BDI-II scores using Spearman's rank order correlation coefficient. Correction for multiple comparisons was performed using the false discovery rate (FDR). Three regions of interest (left rostral anterior cingulate and bilateral orbitofrontal cortex) were found to be significantly correlated with depressive symptoms (FDR 0.05). With FDR 0.1, six regions were significantly correlated. The use of volumetric analysis of brain regions of interest to study post-TBI depression is worthy of further study. Regions associated with depressive symptoms in this pilot study were similar to those implicated in study of spontaneous depression.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalPsychiatry Research - Neuroimaging
Issue number3
StatePublished - Mar 31 2011


  • BDI-II
  • Cerebral atrophy
  • MRI

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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