Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis

Matthew D. Cykowski; John Hicks; David I. Sandberg; Adriana Olar; Julia A. Bridge; Patricia T. Greipp; Patricia Navarro; Steven Kolodziej; Meenakshi B. Bhattacharjee

doi:10.3109/01913123.2014.950778

Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis

Matthew D. Cykowski, John Hicks, David I. Sandberg, Adriana Olar, Julia A. Bridge, Patricia T. Greipp, Patricia Navarro, Steven Kolodziej, Meenakshi B. Bhattacharjee

Hematopathology

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4 Scopus citations

Abstract

We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

Original language	English (US)
Pages (from-to)	69-77
Number of pages	9
Journal	Ultrastructural Pathology
Volume	39
Issue number	1
DOIs	https://doi.org/10.3109/01913123.2014.950778
State	Published - Feb 1 2015

Keywords

Alveolar soft part sarcoma
Brain metastasis
CD68

ASJC Scopus subject areas

Structural Biology
Pathology and Forensic Medicine

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title = "Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis",

abstract = "We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.",

keywords = "Alveolar soft part sarcoma, Brain metastasis, CD68",

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T2 - Ultrastructural features and differential diagnosis

AU - Cykowski, Matthew D.

AU - Hicks, John

AU - Sandberg, David I.

AU - Olar, Adriana

AU - Bridge, Julia A.

AU - Greipp, Patricia T.

AU - Navarro, Patricia

AU - Kolodziej, Steven

AU - Bhattacharjee, Meenakshi B.

N1 - Publisher Copyright: © Informa Healthcare USA, Inc.

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N2 - We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

AB - We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

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KW - Brain metastasis

KW - CD68

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Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis

Abstract

Keywords

ASJC Scopus subject areas

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