BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Aldo A. Acosta-Medina; Paul G. Kemps; Timo C.E. Zondag; Jithma P. Abeykoon; Jelske Forma-Borst; Eline C. Steenwijk; Elizabeth A.M. Feijen; Jop C. Teepen; N. Nora Bennani; Susan M. Schram; Mithun V. Shah; Caroline Davidge-Pitts; Matthew J. Koster; Jay H. Ryu; Robert Vassallo; W. Oliver Tobin; Jason R. Young; Surendra Dasari; Karen Rech; Aishwarya Ravindran; Arjen H.G. Cleven; Robert M. Verdijk; Carel J.M. van Noesel; Brian V. Balgobind; Gerrit Joan Bouma; Peerooz Saeed; Jos A.M. Bramer; Ruben A.L. de Groen; Joost S.P. Vermaat; Michiel A.J. van de Sande; Egbert F. Smit; Anton W. Langerak; Tom van Wezel; Sanne H. Tonino; Cor van den Bos; Jan A.M. van Laar; Ronald S. Go; Gaurav Goyal; Astrid G.S. van Halteren

doi:10.1182/blood.2023021212

BRAF^V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Aldo A. Acosta-Medina, Paul G. Kemps, Timo C.E. Zondag, Jithma P. Abeykoon, Jelske Forma-Borst, Eline C. Steenwijk, Elizabeth A.M. Feijen, Jop C. Teepen, N. Nora Bennani, Susan M. Schram, Mithun V. Shah, Caroline Davidge-Pitts, Matthew J. Koster, Jay H. Ryu, Robert Vassallo, W. Oliver Tobin, Jason R. Young, Surendra Dasari, Karen Rech, Aishwarya RavindranArjen H.G. Cleven, Robert M. Verdijk, Carel J.M. van Noesel, Brian V. Balgobind, Gerrit Joan Bouma, Peerooz Saeed, Jos A.M. Bramer, Ruben A.L. de Groen, Joost S.P. Vermaat, Michiel A.J. van de Sande, Egbert F. Smit, Anton W. Langerak, Tom van Wezel, Sanne H. Tonino, Cor van den Bos, Jan A.M. van Laar, Ronald S. Go, Gaurav Goyal, Astrid G.S. van Halteren

Research output: Contribution to journal › Article › peer-review

Abstract

In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAF^V600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

Original language	English (US)
Pages (from-to)	1570-1575
Number of pages	6
Journal	Blood
Volume	142
Issue number	18
DOIs	https://doi.org/10.1182/blood.2023021212
State	Published - Nov 2 2023

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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Acosta-Medina, A. A., Kemps, P. G., Zondag, T. C. E., Abeykoon, J. P., Forma-Borst, J., Steenwijk, E. C., Feijen, E. A. M., Teepen, J. C., Bennani, N. N., Schram, S. M., Shah, M. V., Davidge-Pitts, C., Koster, M. J., Ryu, J. H., Vassallo, R., Tobin, W. O., Young, J. R., Dasari, S., Rech, K., ... van Halteren, A. G. S. (2023). BRAF^V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis. Blood, 142(18), 1570-1575. https://doi.org/10.1182/blood.2023021212

Acosta-Medina, AA, Kemps, PG, Zondag, TCE, Abeykoon, JP, Forma-Borst, J, Steenwijk, EC, Feijen, EAM, Teepen, JC, Bennani, NN, Schram, SM, Shah, MV, Davidge-Pitts, C, Koster, MJ , Ryu, JH , Vassallo, R , Tobin, WO, Young, JR, Dasari, S, Rech, K, Ravindran, A, Cleven, AHG, Verdijk, RM, van Noesel, CJM, Balgobind, BV, Bouma, GJ, Saeed, P, Bramer, JAM, de Groen, RAL, Vermaat, JSP, van de Sande, MAJ, Smit, EF, Langerak, AW, van Wezel, T, Tonino, SH, van den Bos, C, van Laar, JAM, Go, RS, Goyal, G & van Halteren, AGS 2023, 'BRAF^V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis', Blood, vol. 142, no. 18, pp. 1570-1575. https://doi.org/10.1182/blood.2023021212

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title = "BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis",

abstract = "In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.",

author = "Acosta-Medina, {Aldo A.} and Kemps, {Paul G.} and Zondag, {Timo C.E.} and Abeykoon, {Jithma P.} and Jelske Forma-Borst and Steenwijk, {Eline C.} and Feijen, {Elizabeth A.M.} and Teepen, {Jop C.} and Bennani, {N. Nora} and Schram, {Susan M.} and Shah, {Mithun V.} and Caroline Davidge-Pitts and Koster, {Matthew J.} and Ryu, {Jay H.} and Robert Vassallo and Tobin, {W. Oliver} and Young, {Jason R.} and Surendra Dasari and Karen Rech and Aishwarya Ravindran and Cleven, {Arjen H.G.} and Verdijk, {Robert M.} and {van Noesel}, {Carel J.M.} and Balgobind, {Brian V.} and Bouma, {Gerrit Joan} and Peerooz Saeed and Bramer, {Jos A.M.} and {de Groen}, {Ruben A.L.} and Vermaat, {Joost S.P.} and {van de Sande}, {Michiel A.J.} and Smit, {Egbert F.} and Langerak, {Anton W.} and {van Wezel}, Tom and Tonino, {Sanne H.} and {van den Bos}, Cor and {van Laar}, {Jan A.M.} and Go, {Ronald S.} and Gaurav Goyal and {van Halteren}, {Astrid G.S.}",

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year = "2023",

month = nov,

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doi = "10.1182/blood.2023021212",

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T1 - BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

AU - Acosta-Medina, Aldo A.

AU - Kemps, Paul G.

AU - Zondag, Timo C.E.

AU - Abeykoon, Jithma P.

AU - Forma-Borst, Jelske

AU - Steenwijk, Eline C.

AU - Feijen, Elizabeth A.M.

AU - Teepen, Jop C.

AU - Bennani, N. Nora

AU - Schram, Susan M.

AU - Shah, Mithun V.

AU - Davidge-Pitts, Caroline

AU - Koster, Matthew J.

AU - Ryu, Jay H.

AU - Vassallo, Robert

AU - Tobin, W. Oliver

AU - Young, Jason R.

AU - Dasari, Surendra

AU - Rech, Karen

AU - Ravindran, Aishwarya

AU - Cleven, Arjen H.G.

AU - Verdijk, Robert M.

AU - van Noesel, Carel J.M.

AU - Balgobind, Brian V.

AU - Bouma, Gerrit Joan

AU - Saeed, Peerooz

AU - Bramer, Jos A.M.

AU - de Groen, Ruben A.L.

AU - Vermaat, Joost S.P.

AU - van de Sande, Michiel A.J.

AU - Smit, Egbert F.

AU - Langerak, Anton W.

AU - van Wezel, Tom

AU - Tonino, Sanne H.

AU - van den Bos, Cor

AU - van Laar, Jan A.M.

AU - Go, Ronald S.

AU - Goyal, Gaurav

AU - van Halteren, Astrid G.S.

PY - 2023/11/2

Y1 - 2023/11/2

N2 - In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

AB - In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

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BRAF^V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Abstract

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