Botulinum toxin in the treatment of myofascial pain syndrome

William P. Cheshire, Sandra W. Abashian, J. Douglas Mann

Research output: Contribution to journalArticlepeer-review

292 Scopus citations


Six patients with chronic myofascial pain syndrome involving cervical paraspinal and shoulder girdle muscles received trigger point injections of botulinum toxin type A (Botox) or saline in a randomized, double-blind, placebo-controlled study. Four patients experienced reduction in pain of at least 30% following Botox, but not saline, injections, as measured by visual analog scales, verbal descriptors for pain intensity and unpleasantness, palpable muscle firmness, and pressure pain thresholds. Results were statistically significant. Botox, which inhibits muscle contraction by blocking the release of acetylcholine from peripheral nerves, appears to be an effective treatment for focal myofascial pain disorders.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
Issue number1
StatePublished - Oct 1994


  • Botulinum toxin
  • Myofascial pain syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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