Abstract
A novel bone biopsy technique was used to generate a robust stromal cell system to study how stroma modulates CLL B-cell apoptosis and how the leukemic cell-stromal interaction influences secretion of vascular factors. Marrow stromal elements (MSE) rescued CLL B-cells from both spontaneous and drug induced apoptosis, partly due to soluble factors. When CLL B-cells were added to the MSE cultures, a dramatic increase in the secretion of basic fibroblast growth factor and decrease in the secretion of thrombospondin was observed. These results indicate the interaction between CLL B-cells and marrow stromal elements regulates angiogenic switching and may be linked to disease progression.
Original language | English (US) |
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Pages (from-to) | 899-906 |
Number of pages | 8 |
Journal | Leukemia Research |
Volume | 31 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2007 |
Keywords
- Apoptosis
- CLL
- Marrow
- Stromal cells
- VEGF
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research