Bloodstream infections in patients with transcatheter aortic valve replacement

Khawaja M. Talha, Jack W. McHugh, Daniel C. DeSimone, Karen M. Fischer, Mackram F. Eleid, Jennifer St. Sauver, M. Rizwan Sohail, Larry M. Baddour

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate incidence and risk factors of bloodstream infections (BSI) in patients with transcatheter aortic valve replacement (TAVR). Methods: We conducted a population-based study in southeastern Minnesota using the expanded Rochester Epidemiology Project (e-REP) for all adult (≥18 years) patients who underwent TAVR from January 1, 2010 to December 31, 2018. Results: The incidence of BSI following TAVR was 1300 episodes/100,000 persons per annum. The median time to BSI following TAVR was 610 days and 84% were community-acquired. Forty percent of BSI cases developed infective endocarditis. Viridans group streptococci (VGS) were the most common pathogens and 80% of patients with VGS BSI had IE. Conclusions: The high incidence of BSI among TAVR patients is alarming and is likely due to advanced age and comorbid conditions. Because 40% of BSI patients also developed IE, further investigation of modifiable risk factors associated with BSI is warranted.

Original languageEnglish (US)
Article number115456
JournalDiagnostic Microbiology and Infectious Disease
Issue number3
StatePublished - Nov 2021


  • bloodstream infections
  • incidence
  • infective endocarditis
  • population-based
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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