Blood-brain barrier in acute liver failure

Justin H. Nguyen

doi:10.1016/j.neuint.2011.10.012

Blood-brain barrier in acute liver failure

Justin H. Nguyen

Transplant Surgery

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Brain edema remains a challenging obstacle in the management of acute liver failure (ALF). Cytotoxic mechanisms associated with brain edema have been well recognized, but evidence for vasogenic mechanisms in the pathogenesis of brain edema in ALF has been lacking. Recent reports have not only shown a role of matrix metalloproteinase-9 in the pathogenesis of brain edema in experimental ALF but have also found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. This article reviews and explores the role of the paracellular tight junction proteins in the increased selective BBB permeability that leads to brain edema in ALF.

Original language	English (US)
Pages (from-to)	676-683
Number of pages	8
Journal	Neurochemistry International
Volume	60
Issue number	7
DOIs	https://doi.org/10.1016/j.neuint.2011.10.012
State	Published - Jun 2012

Keywords

Acute liver failure
Brain endothelial cell
Paracellular permeability
Tight junction

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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10.1016/j.neuint.2011.10.012

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title = "Blood-brain barrier in acute liver failure",

abstract = "Brain edema remains a challenging obstacle in the management of acute liver failure (ALF). Cytotoxic mechanisms associated with brain edema have been well recognized, but evidence for vasogenic mechanisms in the pathogenesis of brain edema in ALF has been lacking. Recent reports have not only shown a role of matrix metalloproteinase-9 in the pathogenesis of brain edema in experimental ALF but have also found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. This article reviews and explores the role of the paracellular tight junction proteins in the increased selective BBB permeability that leads to brain edema in ALF.",

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AB - Brain edema remains a challenging obstacle in the management of acute liver failure (ALF). Cytotoxic mechanisms associated with brain edema have been well recognized, but evidence for vasogenic mechanisms in the pathogenesis of brain edema in ALF has been lacking. Recent reports have not only shown a role of matrix metalloproteinase-9 in the pathogenesis of brain edema in experimental ALF but have also found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. This article reviews and explores the role of the paracellular tight junction proteins in the increased selective BBB permeability that leads to brain edema in ALF.

KW - Acute liver failure

KW - Brain endothelial cell

KW - Paracellular permeability

KW - Tight junction

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Blood-brain barrier in acute liver failure

Abstract

Keywords

ASJC Scopus subject areas

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