Bivalent recognition of histone marks by BARD1

Min Deng, Jing Hou, Zhenkun Lou

Research output: Contribution to journalShort surveypeer-review


BARD1 directs BRCA1 to DNA damage sites to facilitate homology recombination. Zhou and colleagues have now determined the cryo-electron microscopy (cryo-EM) structure of BARD1 bound to a nucleosome core particle with two marks: H2AK15ub and H4K20me0. The structure illustrates how bivalent recognition of both marks mediates highly specified recruitment of the BARD1-BRCA1 complex.

Original languageEnglish (US)
Pages (from-to)703-704
Number of pages2
JournalTrends in Cell Biology
Issue number9
StatePublished - Sep 2021


  • BARD1
  • BRCA1
  • cryo-electron microscopy structure
  • homologous recombination
  • nucleosomes

ASJC Scopus subject areas

  • Cell Biology


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