Biphasic pulmonary blastoma with germ cell differentiation in a 36-year-old man

Patrick H. Archie, Mary Beth Beasley, Helen J. Ross

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We describe the clinical and pathologic findings of a young man with a heterogeneous mediastinal tumor metastatic to both lungs, and containing a predominant pattern of classic biphasic pulmonary blastoma with elements of immature teratoma, seminoma, and embryonal carcinoma. Beta-human chorionic gonadotropin and alpha-fetoprotein were elevated at presentation and responded to four cycles of bleomycin, etoposide, and cisplatin although the tumor did not regress. The patient ultimately progressed through paclitaxel, ifosfamide, and cisplatin and tandem autologous bone marrow transplants. Classic biphasic pulmonary blastoma is a rare tumor of young adults. Surgery is the primary treatment, but prognosis is poor and chemotherapy and radiation have been used for unresectable disease. A discussion of pulmonary blastoma and extragonadal germ cell tumors is presented.

Original languageEnglish (US)
Pages (from-to)1185-1187
Number of pages3
JournalJournal of Thoracic Oncology
Issue number10
StatePublished - Oct 2008


  • Extragonadal germ cell tumor
  • Mediastinal mass
  • Pulmonary blastoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine


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