Bioprinting a cardiac valve

Soumen Jana, Amir Lerman

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Heart valve tissue engineering could be a possible solution for the limitations of mechanical and biological prostheses, which are commonly used for heart valve replacement. In tissue engineering, cells are seeded into a 3-dimensional platform, termed the scaffold, to make the engineered tissue construct. However, mimicking the mechanical and spatial heterogeneity of a heart valve structure in a fabricated scaffold with uniform cell distribution is daunting when approached conventionally. Bioprinting is an emerging technique that can produce biological products containing matrix and cells, together or separately with morphological, structural and mechanical diversity. This advance increases the possibility of fabricating the structure of a heart valve in vitro and using it as a functional tissue construct for implantation. This review describes the use of bioprinting technology in heart valve tissue engineering.

Original languageEnglish (US)
Pages (from-to)1503-1521
Number of pages19
JournalBiotechnology Advances
Issue number8
StatePublished - 2015


  • 2-Dimensional printing
  • 3-Dimensional printing
  • Bioprinting
  • Heart valve
  • Hydrogel

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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