Biomedical spectral x-ray imaging; Promises and challenges

Steven M. Jorgensen, Diane R. Eaker, Erik L. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Imaging arrays with sub-millimeter detector pixels that count and allocate energy to each detected photon are now being introduced into biomedical computed tomography scanners. Consequently, bremsstrahlung x-ray can provide the advantages of simultaneous recording of multiple quasi-monochromatic x-ray images which can be used for identification of various materials within the image field. This capability increases the inherent contrast within biomedical CT images and also introduces the ability to use high atomic weight "foreign" elements (e.g., strontium) which are surrogates for "native" biological elements (e.g., calcium) to monitor tissue function (e.g., bone deposition). Challenges for this methodology include limited maximum fluence due to photon pile-up, charge-sharing between contiguous pixels and heterogeneous pixel characteristics due to manufacturing difficulties.

Original languageEnglish (US)
Title of host publicationX-Ray Lasers and Coherent X-Ray Sources
Subtitle of host publicationDevelopment and Applications IX
StatePublished - Dec 1 2011
EventX-Ray Lasers and Coherent X-Ray Sources: Development and Applications IX - San Diego, CA, United States
Duration: Aug 23 2011Aug 25 2011

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherX-Ray Lasers and Coherent X-Ray Sources: Development and Applications IX
Country/TerritoryUnited States
CitySan Diego, CA


  • Beam hardening
  • Charge sharing
  • Clinical CT
  • Dual-energy X-ray
  • Kedge
  • Micro-CT
  • Photon counting
  • Photon pile-up
  • X-ray fluorescence
  • X-ray scatter

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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