Biologic nanoparticles and vascular disease

Research output: Chapter in Book/Report/Conference proceedingChapter


Sustained or repeating chronic infections have been linked to arterial calcification. Biologic nanoparticles (NPs) that propagate in culture have been isolated from calcified soft tissues. When inoculated into experimental animals, NPs appear to exacerbate the arterial response to injury, up to and including medial discontinuity and vascular occlusion. These NPs may be re-assembled proteins and microvesicles derived from mammalian cells and/or microorganisms.

Original languageEnglish (US)
Title of host publicationAtherosclerosis Disease Management
PublisherSpringer New York
Number of pages15
ISBN (Print)9781441972217
StatePublished - 2011


  • Arterial calcification
  • Calcium
  • Hydroxyapatite
  • Infection
  • Inflammation

ASJC Scopus subject areas

  • General Medicine


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