Biocompatibility of a physiological pressure sensor

Chao Yang, Chunfeng Zhao, Lester Wold, Kenton R. Kaufman

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


A newly developed fiber optic micropressure sensor was evaluated for biocompatibility using the International Organization for Standardization (ISO) test standard 10993-6. The test material and an inert control (fused silica glass) were tested in New Zealand white rabbits. Four test specimens were implanted in the paravertebral muscles on one side of the spine about 2-5 cm from the mid-line and parallel to the spinal column. Similarly, four control specimens were implanted on the opposite side. The implantation periods were 1, 4, and 12 weeks to ensure a steady state biological tissue response. Four animals were tested at each time period. Macroscopic and microscopic observations were performed to compare the biological reactions between the test and control materials. There was an inflammatory reaction at 1 week which subsided at 4 weeks. There was fibrous tissue growth near the implant that also decreased over time. Most importantly, there was no significant difference in the biological response between the test and control materials. Therefore, we conclude that the pressure microsensor is biocompatible.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalBiosensors and Bioelectronics
Issue number1
StatePublished - Oct 30 2003


  • Biocompatibility
  • Fiber optic pressure sensor
  • Intramuscular pressure
  • Silica glass
  • Tissue response

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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