Biochemical testing of thyroid function

G. G. Klee, I. D. Hay

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Various published guidelines recommending serum thyrotropin (TSH)-first thyroid testing are outlined. The entities called 'subclinical hypothyroidism' and 'subclinical hyperthyroidism' are defined on the basis of abnormal TSH concentrations and normal values of other biochemical thyroid tests. The controversies about follow-up and treatment of these disorders are discussed. The laboratory experience of Mayo Clinic Rochester in using TSH- first thyroid testing and the subsequent implementation of a thyroid test ordering cascade are presented. Finally, recommendations are given for further optimizing laboratory testing for thyroid disorders.

Original languageEnglish (US)
Pages (from-to)763-775
Number of pages13
JournalEndocrinology and Metabolism Clinics of North America
Issue number4
StatePublished - 1997

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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