Bicuspid aortic valve aortopathy in adults: Incidence, etiology, and clinical significance

Hector I. Michelena, Alessandro Della Corte, Siddharth K. Prakash, Dianna M. Milewicz, Artur Evangelista, Maurice Enriquez-Sarano

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


Bicuspid aortic valve is the most common congenital heart defect and is associated with an aortopathy manifested by dilatation of the ascending thoracic aorta. The clinical consequences of this aortopathy are the need for periodic monitoring of aortic diameters, elective prophylactic surgical aortic repair, and the occurrence of aortic dissection or rupture. This review describes the current knowledge of BAV aortopathy in adults, including incidence, pathophysiologic insights into its etiology, contemporary hypothesis-generating observations into its complications, and recommendations for monitoring and intervention.

Original languageEnglish (US)
Pages (from-to)400-407
Number of pages8
JournalInternational Journal of Cardiology
StatePublished - Oct 10 2015


  • Aortic aneurysm
  • Aortic dissection
  • Bicuspid aortic valve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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