Biased (A→I) hypermutation of animal RNA virus genomes

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75 Scopus citations


RNA genomes evolve largely on the basis of single point mutations introduced by imprecise RNA polymerases, or by recombination. Clusters of certain transitions (biased hypermutations) were detected first in the genomes of persistent viruses, and in the past year have also been found in the genomes of lytic RNA viruses. A cellular RNA-modifying enzyme probably introduces the clustered transitions and thus contributes to the evolution of RNA viruses.

Original languageEnglish (US)
Pages (from-to)895-900
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number6
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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