Beyond mortality: Future clinical research in acute lung injury

Roger G. Spragg, Gordon R. Bernard, William Checkley, J. Randall Curtis, Ognjen Gajic, Gordon Guyatt, Jesse Hall, Elliott Israel, Manu Jain, Dale M. Needham, Adrienne G. Randolph, Gordon D. Rubenfeld, David Schoenfeld, B. Taylor Thompson, Lorraine B. Ware, Duncan Young, Andrea L. Harabin

Research output: Contribution to journalArticlepeer-review

211 Scopus citations


Mortality in National Heart, Lung and Blood Institute - sponsored clinical trials of treatments for acute lung injury (ALI) has decreased dramatically during the past two decades. As a consequence, design of such trials based on a mortality outcome requires ever-increasing numbers of patients. Recognizing that advances in clinical trial design might be applicable to these trials and might allow trials with fewer patients, the National Heart, Lung and Blood Institute convened a workshop of extramural experts from several disciplines. The workshop assessed the current state of clinical research addressing ALI, identified research needs, and recommended: (1) continued performance of trials evaluating treatments of patients with ALI; (2) development of strategies to perform ALI prevention trials; (3) observational studies of patients without ALI undergoing prolonged mechanical ventilation; and (4) development of a standardized format for reporting methods, endpoints, and results of ALI trials.

Original languageEnglish (US)
Pages (from-to)1121-1127
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Issue number10
StatePublished - May 15 2010


  • Acute respiratory distress syndrome
  • Clinical trials
  • Edema
  • Inflammation
  • Pulmonary diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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