Beta2-microglobulin predicts survival in primary systemic amyloidosis

Morie A. Gertz, Robert A. Kyle, Philip R. Greipp, Jerry A. Katzmann, W. Michael O'Fallon

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


purpose: The study assessed whether β2-microglobulin levels predict survival or response in patients with primary systemic amyloidosis without associated multiple myeloma. patients and methods: The study group consisted of 131 untreated patients with biopsy-proven primary systemic amyloidosis diagnosed and evaluated at the Mayo Clinic. No patient had multiple myeloma. The minimum follow-up of surviving patients is 8 years. No patient was lost to follow-up. results: The median survival of patients with an increased β2-microglobulin level was 10.8 months, compared with patients with a normal β2-microglobulin level (less than or equal to 2.7 μg/mL, 0.23 μmol/L) of 32.9 months (p <0.001). In a multivariate proportional-hazards model, the best model included congestive heart failure (p <0.0001) and increased β2-microglobulin levels (p <0.05). After adjustment for the presence of congestive heart failure, β2-microglobulin level remained significant. When the analysis was restricted to those patients with normal renal function, the median survival of those with an elevated β2-microglobulin level was 9.1 months versus 39.4 months for those with a normal level (p <0.001). The serum level of β2-microglobulin was increased in patients with nephrotic-range proteinuria with or without renal insufficiency (p = 0.05). conclusion: The serum β2-microglobulin level should be measured routinely in all patients with primary systemic amyloidosis because it provides a useful objective factor to identify subsets of patients with this disease who have unfavorable outcomes.

Original languageEnglish (US)
Pages (from-to)609-614
Number of pages6
JournalThe American Journal of Medicine
Issue number5
StatePublished - Nov 1990

ASJC Scopus subject areas

  • General Medicine


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