Benign Uterine Diseases

Zaraq Khan, Elizabeth A Stewart

Research output: Chapter in Book/Report/Conference proceedingChapter


The traditional concept of the uterus is that the endometrium is the dynamic tissue, providing an intricate set of functions throughout the menstrual cycle-a process that rarely culminates in implantation and pregnancy. The myometrium has been viewed as an inert tissue, chiefly important during pregnancy and, when abnormal, providing the surgical livelihood of clinical gynecologists. To understand both the physiology of menstruation and the pathophysiology of abnormal uterine bleeding (AUB), both the myometrial and the endometrial layers of the uterus are important. This chapter covers both myometrial disease (adenomyosis and leiomyomas) and endometrial diseases (polyps, AUB, intrauterine adhesions, and dysmenorrhea). The objective is to provide the reader with an understanding of the various clinical presentations as well as the molecular pathophysiology of the disease process and to enlist various therapeutic options for these benign uterine diseases.

Original languageEnglish (US)
Title of host publicationYen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition
PublisherElsevier Inc.
ISBN (Electronic)9780323582322
ISBN (Print)9780323479127
StatePublished - Feb 16 2018


  • Abnormal uterine bleeding
  • Adenomyosis
  • Asherman syndrome
  • Dysmenorrhea
  • Endometrial polyps
  • Intrauterine adhesions
  • Leiomyoma
  • Magnetic resonance-guided focused ultrasound surgery
  • Myomectomy
  • Uterine artery embolization
  • Uterine fibroids

ASJC Scopus subject areas

  • General Medicine


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