Barrett's Esophagus

I. J.M. Levink, M. B. Wallace

Research output: Chapter in Book/Report/Conference proceedingChapter


Barrett's esophagus (BE) is a premalignant condition in which the normal stratified squamous epithelium of the distal esophagus is replaced by columnar intestinal-type epithelium. The incidence of progression to esophageal adenocarcinoma (EAC) is relatively low. However, once EAC has developed, the mortality is high. Intensive surveillance, followed by BE treatment, tends to prevent malignant progression. During the last decade, multiple imaging and contrast enhancement methods have been developed to overcome the drawbacks of standard endoscopic inspection and random biopsies (i.e., Seattle protocol). Future studies will prove which imaging modalities are here to stay and will assist (or even replace) this biopsy method.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Gastroenterology, Second Edition
Number of pages13
ISBN (Electronic)9780128124604
StatePublished - Jan 1 2019


  • Barrett's esophagus
  • Chromoendoscopy
  • Confocal laser endomicroscopy
  • Endoscopic mucosal resection
  • Esophagogastroduodenoscopy
  • Helicobacter pylori
  • Intestinal metaplasia
  • Narrow band imaging
  • Radiofrequency ablation
  • Seattle protocol
  • Surveillance
  • Volumetric laser endomicroscopy

ASJC Scopus subject areas

  • General Medicine


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