Bare fiber photodynamic therapy using porfimer sodium for esophageal disease

Herbert Wolfsen, Marcia Canto, Bob Etemad, Bruce Greenwald, Frank Gress, Drew Schembre, V. Raman Muthusamy, Afonso Ribeiro, Virender Sharma, Gregory Ginsberg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


During Digestive Disease Week 2005 in Chicago, Illinois, our group of 10 gastrointestinal photodynamic therapists met to discuss variations in procedural technique and treatment protocols. An extensive review of the use of photodynamic therapy (PDT) for esophageal disease has recently been published elsewhere [Wolfsen HC. Present status of photodynamic therapy for high-grade dysplasia in Barrett's esophagus. J Clin Gastroenterol 2005;39(3):189-202]. This report, based mostly on clinical experience and common sense rather than evidence-based medicine, is a detailed discussion of pragmatic issues. In summary, our centers treat patients with Barrett's dysplasia, Barrett's or squamous cell carcinoma using the photosensitizer porfimer sodium (2 mg/kg total body weight) and bare fiber PDT (no fiber centering devices). Aggressive suppression of gastric acid is uniformly emphasized. The most common technique variables were the light energy source, light dosimetry and the amount of Barrett's mucosa treated during a course of PDT. Standardization of porfimer sodium PDT procedures and light dosimetry may enhance treatment outcomes.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalPhotodiagnosis and Photodynamic Therapy
Issue number2
StatePublished - Jun 1 2006


  • Endobronchial ultrasound
  • Endoscopic ultrasound
  • Lung cancer
  • Phototoxicity
  • Stricture

ASJC Scopus subject areas

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)


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