TY - JOUR
T1 - Banff 2022 pancreas transplantation multidisciplinary report
T2 - Refinement of guidelines for T cell–mediated rejection, antibody-mediated rejection and islet pathology. Assessment of duodenal cuff biopsies and noninvasive diagnostic methods
AU - Drachenberg, Cinthia B.
AU - Buettner-Herold, Maike
AU - Aguiar, Pedro Ventura
AU - Horsfield, Catherine
AU - Mikhailov, Alexei V.
AU - Papadimitriou, John C.
AU - Seshan, Surya V.
AU - Perosa, Marcelo
AU - Boggi, Ugo
AU - Uva, Pablo
AU - Rickels, Michael
AU - Grzyb, Krzyztof
AU - Arend, Lois
AU - Cuatrecasas, Miriam
AU - Toniolo, Maria Fernanda
AU - Farris, Alton B.
AU - Renaudin, Karine
AU - Zhang, Lizhi
AU - Roufousse, Candice
AU - Gruessner, Angelika
AU - Gruessner, Rainer
AU - Kandaswamy, Raja
AU - White, Steven
AU - Burke, George
AU - Cantarovich, Diego
AU - Parsons, Ronald F.
AU - Cooper, Matthew
AU - Kudva, Yogish C.
AU - Kukla, Aleksandra
AU - Haririan, Abdolreza
AU - Parajuli, Sandesh
AU - Merino-Torres, Juan Francisco
AU - Argente-Pla, Maria
AU - Meier, Raphael
AU - Dunn, Ty
AU - Ugarte, Richard
AU - Rao, Joseph Sushil
AU - Vistoli, Fabio
AU - Stratta, Robert
AU - Odorico, Jon
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2024/3
Y1 - 2024/3
N2 - The Banff pancreas working schema for diagnosis and grading of rejection is widely used for treatment guidance and risk stratification in centers that perform pancreas allograft biopsies. Since the last update, various studies have provided additional insight regarding the application of the schema and enhanced our understanding of additional clinicopathologic entities. This update aims to clarify terminology and lesion description for T cell–mediated and antibody-mediated allograft rejections, in both active and chronic forms. In addition, morphologic and immunohistochemical tools are described to help distinguish rejection from nonrejection pathologies. For the first time, a clinicopathologic approach to islet pathology in the early and late posttransplant periods is discussed. This update also includes a discussion and recommendations on the utilization of endoscopic duodenal donor cuff biopsies as surrogates for pancreas biopsies in various clinical settings. Finally, an analysis and recommendations on the use of donor-derived cell-free DNA for monitoring pancreas graft recipients are provided. This multidisciplinary effort assesses the current role of pancreas allograft biopsies and offers practical guidelines that can be helpful to pancreas transplant practitioners as well as experienced pathologists and pathologists in training.
AB - The Banff pancreas working schema for diagnosis and grading of rejection is widely used for treatment guidance and risk stratification in centers that perform pancreas allograft biopsies. Since the last update, various studies have provided additional insight regarding the application of the schema and enhanced our understanding of additional clinicopathologic entities. This update aims to clarify terminology and lesion description for T cell–mediated and antibody-mediated allograft rejections, in both active and chronic forms. In addition, morphologic and immunohistochemical tools are described to help distinguish rejection from nonrejection pathologies. For the first time, a clinicopathologic approach to islet pathology in the early and late posttransplant periods is discussed. This update also includes a discussion and recommendations on the utilization of endoscopic duodenal donor cuff biopsies as surrogates for pancreas biopsies in various clinical settings. Finally, an analysis and recommendations on the use of donor-derived cell-free DNA for monitoring pancreas graft recipients are provided. This multidisciplinary effort assesses the current role of pancreas allograft biopsies and offers practical guidelines that can be helpful to pancreas transplant practitioners as well as experienced pathologists and pathologists in training.
KW - acute T cell–mediated rejection
KW - antibody-mediated rejection
KW - donor-specific antibody
KW - mixed rejection
KW - pancreas after kidney transplant
KW - percutaneous pancreas biopsy
KW - simultaneous pancreas kidney transplant
KW - solitary pancreas transplant
KW - whole pancreas transplantation
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U2 - 10.1016/j.ajt.2023.10.011
DO - 10.1016/j.ajt.2023.10.011
M3 - Article
C2 - 37871799
AN - SCOPUS:85178212289
SN - 1600-6135
VL - 24
SP - 362
EP - 379
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 3
ER -