TY - JOUR
T1 - Banff 2022 Liver Group Meeting report
T2 - Monitoring long-term allograft health
AU - Bellamy, Christopher O.C.
AU - O'Leary, Jacqueline G.
AU - Adeyi, Oyedele
AU - Baddour, Nahed
AU - Batal, Ibrahim
AU - Bucuvalas, John
AU - Del Bello, Arnaud
AU - El Hag, Mohamed
AU - El-Monayeri, Magda
AU - Farris, Alton B.
AU - Feng, Sandy
AU - Fiel, Maria Isabel
AU - Fischer, Sandra E.
AU - Fung, John
AU - Grzyb, Krzysztof
AU - Guimei, Maha
AU - Haga, Hironori
AU - Hart, John
AU - Jackson, Annette M.
AU - Jaeckel, Elmar
AU - Khurram, Nigar A.
AU - Knechtle, Stuart J.
AU - Lesniak, Drew
AU - Levitsky, Josh
AU - McCaughan, Geoff
AU - McKenzie, Catriona
AU - Mescoli, Claudia
AU - Miquel, Rosa
AU - Minervini, Marta I.
AU - Nasser, Imad Ahmad
AU - Neil, Desley
AU - O'Neil, Maura F.
AU - Pappo, Orit
AU - Randhawa, Parmjeet
AU - Ruiz, Phillip
AU - Fueyo, Alberto Sanchez
AU - Schady, Deborah
AU - Schiano, Thomas
AU - Sebagh, Mylene
AU - Smith, Maxwell
AU - Stevenson, Heather L.
AU - Taner, Timucin
AU - Taubert, Richard
AU - Thung, Swan
AU - Trunecka, Pavel
AU - Wang, Hanlin L.
AU - Wood-Trageser, Michelle
AU - Yilmaz, Funda
AU - Zen, Yoh
AU - Zeevi, Adriana
AU - Demetris, Anthony J.
N1 - Publisher Copyright:
© 2024
PY - 2024
Y1 - 2024
N2 - The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including noninvasive and tissue monitoring, immunosuppression optimization, and long-term structural changes. Potential revision of the rejection classification scheme to better accommodate and communicate late T cell-mediated rejection patterns and related structural changes, such as nodular regenerative hyperplasia, were discussed. Improved stratification of long-term maintenance immunosuppression to match the heterogeneity of patient settings will be central to improving long-term patient survival. Such personalized therapeutics are in turn contingent on a better understanding and monitoring of allograft status within a rational decision-making approach, likely to be facilitated in implementation with emerging decision-support tools. Proposed revisions to rejection classification emerging from the meeting include the incorporation of interface hepatitis and fibrosis staging. These will be opened to online testing, modified accordingly, and subject to consensus discussion leading up to the next Banff conference.
AB - The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including noninvasive and tissue monitoring, immunosuppression optimization, and long-term structural changes. Potential revision of the rejection classification scheme to better accommodate and communicate late T cell-mediated rejection patterns and related structural changes, such as nodular regenerative hyperplasia, were discussed. Improved stratification of long-term maintenance immunosuppression to match the heterogeneity of patient settings will be central to improving long-term patient survival. Such personalized therapeutics are in turn contingent on a better understanding and monitoring of allograft status within a rational decision-making approach, likely to be facilitated in implementation with emerging decision-support tools. Proposed revisions to rejection classification emerging from the meeting include the incorporation of interface hepatitis and fibrosis staging. These will be opened to online testing, modified accordingly, and subject to consensus discussion leading up to the next Banff conference.
KW - alloimmunity
KW - anatomy
KW - antibody-mediated rejection
KW - Banff classification
KW - immunosuppression
KW - liver transplantation
KW - pathology
KW - protocol biopsy
KW - T cell-mediated rejection
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U2 - 10.1016/j.ajt.2024.03.008
DO - 10.1016/j.ajt.2024.03.008
M3 - Article
C2 - 38461883
AN - SCOPUS:85188418055
SN - 1600-6135
JO - American Journal of Transplantation
JF - American Journal of Transplantation
ER -